Chitosan has received much attention as a functional biopolymer for diverse\r\napplications, especially in pharmaceutics and medicine. Our recent efforts focused on the\r\nchemical and biological modification of chitosan in order to increase its solubility in\r\naqueous solutions and absorbability in the in vivo system, thus for a better use of chitosan.\r\nThis review summarizes chitosan modification and its pharmaceutical/biomedical\r\napplications based on our achievements as well as the domestic and overseas developments:\r\n(1) enzymatic preparation of low molecular weight chitosans/chitooligosaccharides with\r\ntheir hypocholesterolemic and immuno-modulating effects; (2) the effects of chitin,\r\nchitosan and their derivatives on blood hemostasis; and (3) synthesis of a non-toxic ion\r\nligandââ?¬â?D-Glucosaminic acid from Oxidation of D-Glucosamine for cancer and\r\ndiabetes therapy.
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